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Article Dans Une Revue Cancer Cell Année : 2024

Melanoma and microbiota: Current understanding and future directions

1 University of Montreal Research Center (CRCHUM), Montreal, QC H2X 0A9, Canada; Hematology-Oncology Division, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC H2X 3E4
2 Melanoma Research Alliance, 730 15th Street NW, Washington, DC 20005
3 Seerave Foundation, The Seerave Foundation, 35-37 New Street, St Helier, JE2 3RA Jersey
4 Oncology Discovery Research, AbbVie Inc, North Chicago, IL 60064
5 Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854
6 Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080
7 MaaT Pharma, 69007 Lyon
8 Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO 80045
9 Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213
10 Gustave Roussy Cancer Center, ClinicoBiome, 94805 Villejuif, France; Université Paris Saclay, Faculty of Medicine, 94270 Kremlin Bicêtre,
11 Departments of Immunology & Microbiology and Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037
12 University of Groningen [Groningen]
13 Bio-Me, 0349 Oslo
14 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
15 CRSA - Centre de Recherche Saint-Antoine
16 Department of Physiology & Pharmacology, Snyder Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
17 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA USA
18 Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
19 Sanford Burnham Prebys Discovery Medical Research Institute, La Jolla, CA 92037, USA
20 Weizmann Institute of Science, Computer Science and Applied Mathematics Department, 234th Herzel st., Rehovot 7610001, Israel
21 Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Micronoma Inc., San Diego, CA 92121, USA
22 Johns Hopkins School of Medicine, Department of Oncology, Baltimore, MD 21287, USA
23 Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
24 Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
25 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065
26 Department of Molecular Biology and Biochemistry, University of California, Irvine Irvine, CA 92697-2025, USA
27 Department of Biochemistry and Microbiology, New Jersey Institute of Food, Nutrition and Health, Rutgers University, New Brunswick, NY 08901
28 Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
29 UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA
30 Gustave Roussy Cancer Center, ClinicoBiome, 94805 Villejuif,
Morten Isaksen
  • Fonction : Auteur

Résumé

Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria act on distal tumors and how to harness this complex ecosystem to circumvent primary resistance to immune checkpoint inhibitors. Here, we review the state of the microbiota field in the context of melanoma, the recent breakthroughs in defining microbial modes of action, and how to modulate the microbiota to enhance response to cancer immunotherapy. The host-microbe interaction may be deciphered by the use of "omics" technologies, and will guide patient stratification and the development of microbiota-centered interventions. Efforts needed to advance the field and current gaps of knowledge are also discussed.
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Dates et versions

hal-04599809 , version 1 (04-06-2024)

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Bertrand Routy, Tanisha Jackson, Laura Mählmann, Christina K Baumgartner, Martin Blaser, et al.. Melanoma and microbiota: Current understanding and future directions. Cancer Cell, 2024, 42 (1), pp.16-34. ⟨10.1016/j.ccell.2023.12.003⟩. ⟨hal-04599809⟩
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