COVID-19 Infection among Patients with Autoinflammatory Diseases: A Study on 117 French Patients Compared with 1545 from the French RMD COVID-19 Cohort: COVIMAI \textendash the French Cohort Study of SARS-CoV-2 Infection in Patient with Systemic Autoinflammatory Diseases - Centre de recherche Saint-Antoine - UMR S938 Accéder directement au contenu
Article Dans Une Revue RMD Open : Rheumatic & Musculoskeletal Diseases Année : 2022

COVID-19 Infection among Patients with Autoinflammatory Diseases: A Study on 117 French Patients Compared with 1545 from the French RMD COVID-19 Cohort: COVIMAI \textendash the French Cohort Study of SARS-CoV-2 Infection in Patient with Systemic Autoinflammatory Diseases

1 CHU Tenon [AP-HP]
2 CeRéMAIA - Hôpital André Mignot - Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles]
3 SU - Sorbonne Université
4 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
5 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
6 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
7 UP11 - Université Paris-Sud - Paris 11
8 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
9 Hôpital Cochin [AP-HP]
10 UPCité - Université Paris Cité
11 Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy]
12 AP-HP - Hopital Saint-Louis [AP-HP]
13 IRSL - Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH)
14 CHU Pitié-Salpêtrière [AP-HP]
15 PEPITES - Pharmacoépidémiologie et évaluation des soins [iPLesp]
16 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
17 Groupe Hospitalier du Havre
18 CeRAINO - Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France
19 INFINITE - Institute for Translational Research in Inflammation - U 1286
20 HIA Begin - Hôpital d'Instruction des Armées Begin [Saint-Mandé, France]
21 CHU Nice - Centre Hospitalier Universitaire de Nice
22 CRSA - Centre de Recherche Saint-Antoine
23 CHU Saint-Antoine [AP-HP]
24 UNSA - Université de Nice Sophia-Antipolis
25 Groupe Hospitalier Diaconesses Croix Saint-Simon
26 CH Bar-le-Duc - Centre hospitalier Bar le Duc
27 Université de Lille
Jerome Avouac

Résumé

Objective There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared. Methods A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days. Results We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet' disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted. Conclusion As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.
Fichier principal
Vignette du fichier
e002063.full.pdf (497.46 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04418508 , version 1 (05-06-2024)

Identifiants

Citer

Rim Bourguiba, Maeva Kyheng, Isabelle Koné-Paut, Diane Rouzaud, Jerome Avouac, et al.. COVID-19 Infection among Patients with Autoinflammatory Diseases: A Study on 117 French Patients Compared with 1545 from the French RMD COVID-19 Cohort: COVIMAI \textendash the French Cohort Study of SARS-CoV-2 Infection in Patient with Systemic Autoinflammatory Diseases. RMD Open : Rheumatic & Musculoskeletal Diseases, 2022, 8 (1), pp.e002063. ⟨10.1136/rmdopen-2021-002063⟩. ⟨hal-04418508⟩
20 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More